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University of York
October 15, 2020
Hypoxia inducible factor (HIF) programming in blood stem cells
My lab focuses on the hypoxia inducible factor (HIF), and deciphering the molecular mechanisms which determine its context-dependent transcriptional function and resulting phenotypes in normal and pre-leukaemia blood stem cells. HIF function has been demonstrated as central to these processes, however its effects are very context-dependent. Our lab applies fate-choice decisions in long term HSCs as a model to decipher the mechanisms which dictate HIF function, to investigate how we can direct the power of this master regulator into a force for good in pre-leukaemic disease.