University of Pavia
Extracellular matrix components and megakaryocyte function regulation in health and disease
June 11, 2020
Vittorio Abbonante, PhD, is an Assistant Professor whose research focuses on the study of the microenvironment involvement in controlling bone marrow homeostasis, with particular attention to megakaryocyte differentiation and platelet release.
Recently he has studied the expression of new collagen receptors and mechano-sensitive ion channels by megakaryocytes and their role in modulating cell function. Actually, he is involved in studying the connection of the stromal and megakaryocytic lineages in the pathogenesis of primary myelofibrosis.
megakaryocyte bone marrow, extracellular matrix, mechanobiology, ion flows