University of Pennsylvania
Integration of platelet signaling and coagulation in vivo
June 12, 2020
My research examines the spatiotemporal relationships among hemostatic system components and how they are shaped by local physical forces within the vasculature. Such studies help us understand the impact of current anti-thrombotic therapeutics and may lead to the identification of new targets that better uncouple anti-thrombotic efficacy and bleeding risk. To study these phenomena, I make extensive use of intravital imaging approaches to visualize platelets and coagulation system function during hemostasis and thrombosis in various physiologic contexts.
hemostasis, thrombosis, platelets, intravital, animal models
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