Erasmus University Medical Center, Rotterdam
Weibel-Palade bodies: emergency kits of the vasculature
July 14, 2020
Dr. Ruben Bierings earned his doctoral degree at the Utrecht University (NL) with Dr. Jan van Mourik and Dr. Jan Voorberg, working on storage and secretion of VWF in endothelial cells. As a postdoc with Dr. Tom Carter at the MRC National Institute for Medical Research (London, UK) he studied the role of Rab GTPases and effectors in secretory organelle exocytosis. He is now a group leader at the department of Hematology, Erasmus MC (Rotterdam, NL).
In our lab we study the molecular mechanisms of secretion. Specifically, we aim to unravel how secretory organelles such as Weibel-Palade bodies (WPBs) in endothelial cells or alpha- and dense granules in platelets are formed, how they acquire their exocytotic machinery and how they undergo exocytosis. Some of the recent work has focussed on SNARE proteins, using ex vivo blood outgrowth endothelial cells of patients with bleeding abnormalities or with genetic defects in components of the secretory machinery
Keywords
endothelial cells, Von Willebrand factor, Weibel-Palade bodies, exocytosis, hemostasis
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