MATEUSZ ANTOSZEWSKI

Tcf-1 regulates epigenetic landscape in Notch1-driven T-ALL

May 28, 2020

Last year PhD student at EPFL in Lausanne, Switzerland. About to graduate in 2021 at eager to stay in academia. Currently working on the Notch1-driven T-ALL in Freddy Radtke’s lab.
We are investigating fundamental biology questions in the initiation of T cell acute lymphoblastic leukemia. In particular, how Tcf-1, downstream of Notch1, shapes the chromatin for leukemogenesis processes, already at the level of hematopoietic stem cells.
I started my academic career by obtaining engineering degree in biotechnology at my hometown, Poznan in Poland. Then I moved to KU Leuven in Belgium to then perform Master thesis work in lab of Massimiliano Mazzone on podoplanin-expressing macrophages in breast cancer.
At EPFL we are thoroughly investigating epigenetic regulations by genomic approaches, i.e. ChIP-seq, ATAC-seq, in situ Hi-C, which are then validated in mouse models.