Albert Einstein College of Medicine

PI3 kinase in hematopoietic stem cells

May 8, 2020

Dr. Kira Gritsman is an Associate Professor at Albert Einstein College of Medicine. Her research focuses on how signaling pathways in hematopoietic stem cells (HSCs) and leukemic or pre-leukemic stem cells affect their self-renewal and lineage fate decisions. Her research has uncovered important roles for PI3 kinase (PI3K) and AKT in myeloid malignancies, and in HSC function. Her lab is now investigating the redundant roles of PI3K isoforms in HSC self-renewal and differentiation, both at steady state and under stress. Her research aims to develop safe strategies to target signaling pathways to prevent the initiation and progression of myeloid malignancies.


PI3K, HSC, LSC, leukemia

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